Matthew Chan Tak Vai (陳德威)

  • mtv-chanAcademic qualifications:

1990    University of New South Wales, Australia, MB BS (Hons)

1997    Australian and New Zealand College of Anaesthetists (ANZCA), FANZCA

1997    Hong Kong College of Anaesthesiologists (HKCA), FHKCA

1997    Hong Kong Academy of Medicine (HKAM), FHKAM (Anaesthesiology)

2015    University of Hong Kong, PhD

  • Previous Academic Positions:

Associate Professor (2000-2003), CUHK

Visiting Lecturer, Master of Medicine Program, National University of Singapore (Anesthetic pharmacology 1998, 2000); (Clinical anesthesia 2007, 2010, 2011, 2015)

Visiting Research Fellow, University of New South Wales, Australia (2008-2012)

Visiting Professor, State University of New York (2011)

  • Present Positions:

Professor, CUHK (2003-; tenured 2005-);

Honorary consultant, Prince of Wales Hospital (2000-), Tuen Mun Hospital (2007-);

Visiting Professor, Capital Medical University, Beijing, China (2013-)

Editorial Board Member – British Journal of Anaesthesia (2013-), Canadian Journal of Anaesthesia (2015-) and Journal of Neurosurgical Anesthesiology (2009-; Review Articles Editor 2013-);

Member, Research Committee, ANZCA (2012-);

Faculty member of National Clinical Research Center for Neurological Diseases (NCRC-ND) in China (2013-);

Executive member, ANZCA Clinical Trials Network (2006-)

Peer Review Member, Project Grant Competition, Canadian Institutes of Health Research, 2016


  • Research Experiences:

Over 200 publications in indexed journals (ResearcherID: J-2884-2013).

Principal (and Co-principal) investigator of a number of large clinical trials (*completed):

  • The Vascular events In Surgery patIents cOhort evaluatioN – Cardiac Surgery study (n=15,000; NCT01842568),
  • The Balanced Anesthesia Trial (n=6,500; ACTRN12612000632897),
  • Perioperative ADministration of Dexamethasone and Infection (PADDI) Trial (n=8,800; ACTRN12614001226695),
  • Postoperative vascular complications in unrecognized Obstructive Sleep Apnea (POSA) Trial (n=1,200; NCT01494181),*
  • Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Study (n=40,000; NCT00512109),*
  • Persistent Pain after Surgery Study (n=5,000; ChiCTR-ONC-10001099)*
  • Intravenous Magnesium sulfate in Aneurysmal Subarachnoid Haemorrhage (iMASH) Trial (n=327; NCT00124150),*
  • Evaluation of Nitrous oxide In the Gas Mixture for Anaesthesia (ENIGMA) Trial (n=2,050; NCT00164047)* and ENIGMA II (n=7,112; NCT00430989) trial,*
  • BIS Monitoring to prevent Awareness during anaesthesia: the B-Aware Trial (n=2,463).*


  • Publication records:

Section A – Five recent representative publications:

  1. Chan MTV*, Peyton PJ, Myles PS, Leslie K, Buckley N, Kasza J, Paech MJ, Beattie WS, Sessler DI, Forbes A, Wallace S, Chen Y, Tian YY, Wu WKK, Australian and New Zealand College of Anaesthetists Clinical Trials Network for the ENIGMA-II investigators. Chronic Postsurgical Pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA) – II Trial. Br J Anaesth 2016; doi:1093/bja/aew338)
  2. Liu X, Tian Y, Meng Z, Chen Y, Ho IH, Choy KW, Lichtner P, Wong SH, Yu J, Gin T, Wu WK, Cheng CH, Chan MTV*. Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study. Anesthesiology. 2015 Oct;123(4):838-50
  3. Myles PS, Leslie K, Chan MTV, Forbes A, Peyton PJ, Paech MJ, Beattie WS, Sessler DI, Devereaux PJ, Silbert B, Schricker T, Wallace S, and the ANZCA Trials Group for the ENIGMA-II Investigators: The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial. Lancet 2014; 384: 1446-54
  4. Devereaux PJ, Mrkobrada M, Sessler DI, Leslie K, Alonso-Coello P, Kurz A, Villar JC, Sigamani A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G, Robinson A, Garg AX, Rodseth RN, Botto F, Lurati Buse G, Xavier D, Chan MTV (author 19 out of 47), Tiboni M, Cook D, Kumar PA, Forget P, Malaga G, Fleischmann E, Amir M, Eikelboom J, Mizera R, Torres D, Wang CY, VanHelder T, Paniagua P, Berwanger O, Srinathan S, Graham M, Pasin L, Le Manach Y, Gao P, Pogue J, Whitlock R, Lamy A, Kearon C, Baigent C, Chow C, Pettit S, Chrolavicius S, Yusuf S, for the POISE-2 Investigators: Aspirin in patients undergoing noncardiac surgery. N Engl J Med 2014; 370: 1494-503
  5. Devereaux PJ, Chan MTV (author 2 out of 40), Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI, Jacka MJ, Sigamani A, Srinathan S, Biccard BM, Chow CK, Abraham V, Tiboni M, Pettit S, Szczeklik W, Buse GL, Botto F, Guyatt G, Heels-Ansdell D, Sessler DI, Thorlund K, Garg AX, Mrkobrada M, Thomas S, Rodseth RN, Pearse RM, Thabane L, McQueen MJ, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk CA, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S, Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study Investigators: Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery JAMA 2012; 307: 2295-304


Section B – Five other representative publications:

  1. Chan MTV*, Wan AC, Gin T, Leslie K, Myles PS: Chronic postsurgical pain after nitrous oxide anesthesia. Pain 2011; 152: 2514-20
  2. Graham AM, Myles PS, Leslie K, Chan MTV, Paech MJ, Peyton P, El Dawlatly. A cost-benefit analysis of the ENIGMA trial. Anesthesiology 2011; 115:265-72.
  3. Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Malaga G, Avezum A, Chan MTV, Montori VM, Jacka M, Choi P, POISE Study Group: Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008; 371: 1839-47
  4. Myles PS, Leslie K, Chan MTV, Forbes A, Paech MJ, Peyton P, Silbert BS, Pascoe E: Avoidance of nitrous oxide for patients undergoing major surgery: A randomized controlled trial. Anesthesiology 2007; 107: 221-31
  5. Myles PS, Leslie K, McNeil J, Forbes A, Chan MTV*: Bispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial. Lancet 2004; 363: 1757-63


  • Others: Research-related prizes and awards:
  1. St Jude Medical Research Award (2009)
  2. Harry Daly Research Award (2010, 2014, 2016)
  3. Pfizer ANZCA Research Fellowship (2011)
  4. Mundipharma ANZCA Research Award (2013)
  5. Lennard Travers Professor of Anaesthesia (2015)